Region Jnkpings ln Odontologiska Institutionen

Treatment with oral implants in X-linked hypophosphataemic rickets and hypophosphatasia – report from a workshop

Bergendal  B*, Ö Ljunggren


The aim of the workshop was to establish the prognosis for treatment with oral implants in individuals affected by X-linked Hypophosphataemic Rickets or Hypophosphatasia.


In the rare diagnoses X-linked Hypophosphataemic rickets (XHPR) and Hypophosphatasia (HP) early tooth loss is a significant feature. The question about the risk of failure in implant treatment in individuals with these two diagnoses of osteomalacia was raised in inquiries to the National Oral Disability Centre in Jönköping.

Materials and methods

By inviting Swedish specialists in oral- and maxillofacial surgery, periodontology, and prosthodontics from six clinics with experience in implant treatment in individuals with XHPR and HP and an endocrinologist to a workshop, data on treatment outcome could be compiled. A mailed questionnaire was thereafter sent to 40 Swedish clinics for maxillofacial and implant surgery to enquire about any other treated cases. A second workshop was held in April 2001 to analyse the results further.


All six reported patients were male, aged 22-51 years, and all but one were of short stature and had bowed tibiae. All had a reduced number of natural teeth, and the patients with XHPR had an unusually high number of root-filled teeth. Some of the patients were uninformed of their diagnosis. In three patients with XHPR, ten implants had been installed and eight lost. In three patients with HP, 13 implants had been installed and successfully osseointegrated and none lost.


Results from three patients with XHPR strongly indicate a doubtful prognosis for treatment with oral implants whereas treatment outcomes for three patients with HP were successful in a shortterm perspective. This retrospective report can not explain the reason for the loss of implants.

Uppdaterad: 2013-04-03
Anna Thofelt, Avdelningen för odontologisk radiologi Jönköping, Folktandvården